Lead, Innovate, Transform
AEON Biopharma is a bio-pharmaceutical company focused on developing a proprietary 900 kDabotulinum toxin complex, ABP-450, for debilitating medical conditions. We are committed to developing novel and proprietary treatment paradigms to improve patient outcomes and drive enhanced value to patients, physicians, and payers.
ABP-450 (prabotulinumtoxinA) Injection
ABP-450 contains a 900 kDa botulinum toxin type-A complex produced by the bacterium Clostridium botulinum. When injected at therapeutic doses, ABP-450 causes a chemical denervation of the muscle resulting in localized reduction of muscle activity.
Botulinum toxin type-A specifically blocks peripheral acetylcholine release at presynaptic cholinergic nerve terminals by cleaving SNAP-25, a protein integral to the successful docking and release of acetylcholine from vesicles situated within the nerve endings leading to denervation and relaxation of the muscle.
ABP-450 is the same botulinum toxin complex that has been approved in the United States, the European Union and Canada for an aesthetic indication. To support this aesthetic indication, Daewoong’s aesthetic partner completed a Phase 3 head-to-head study with ABP-450 that showed non-inferiority to Botox® at 20 units. Our strategic partner, Daewoong Pharmaceutical Co., Ltd., has also completed head-to-head studies with ABP-450 that showed non-inferiority to Botox® at various doses ranging from 20 units to 360 units.
We are dedicated to enhancing patient lives by leading in new ways to use botulinum toxins while improving existing botulinum toxin therapy.
Our core values guide our company and
every decision we make.
We recognize the great promise and value that comes from fresh and creative thinking. We aim to transform the therapeutic use of botulinum toxins with the introduction of ABP-450.
At AEON, we believe that great achievements are realized when passionate people work together towards a compelling vision.
We understand how difficult it is to suffer from the pain and decreased functionality arising from medical disorder. At AEON, patients are at the heart of everything we do.
We understand that to innovate we must look forward constantly, adapt effectively and implement quickly.
We believe in building an inspiring vision, setting the direction, and blazing new trails.
Interested in AEON Biopharma?
At AEON Biopharma, our mission is to provide the best value in medicine by bringing innovation with our proprietary botulinum toxin complex.
Learn more about us and our breakthrough botulinum toxin treatments